Endocrine Abstracts

Objective: To conduct a systematic review and meta-analysis of observational, cross sectional and longitudinal studies of sleep apnoea syndrome in acromegalic subjects to determine a) prevalence b) effect of treatment and c) relationship to GH and/or IGF-1.Method: A PubMed search using ‘(acromegaly) AND (sleep apnoea)’ as search terms was performed with subsequent hand searching of relevant papers. Cross sectional and longitudinal studies were ...

Locus-specific databases (LSDBs) have been recently developed in response to the increasing number of genetic changes reported in the human genome. LSDBs have been created for several genes implicated in endocrine syndromes, for example MEN1, VHL, RET, GNAS, PRKAR1A and the SDH subunits. Mutations in AIP are found in about 20% of familial isolated pituitary adenoma (FIPA) patients.The aim of this proj...